Man United's youngsters open their UEFA Youth League campaign.
New signings Arnau Puigmal and Largie Ramazani are named.
United's schedule mirrors that of the first team, playing Benfica, Basel and CSKA Moscow.
The Scotsman previously managed the U21s from 2002-2005.
Man Utd will face Northern Ireland in a curtain-raiser for the SuperCupNI on July 22 at Coleraine Showgrounds.